Effect of grapefruit juice on clarithromycin pharmacokinetics.
Cheng KL, Nafziger AN, Peloquin CA, Amsden GW
To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.
Cheng KL, Nafziger AN, Peloquin CA et al. Effect of Grapefruit Juice on Clarithormycin Pharmacokinetics. Antimicrob Agents Chemother 1998; 42: 927-9.