Antimicrob Agents Chemother 2002 May;46(5):1589-90.
Single-dose pharmacokinetics of amprenavir coadministered with grapefruit juice.
Demarles D, Gillotin C, Bonaventure-Paci S, Vincent I, Fosse S, Taburet AM.
In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (Cmax) compared to administration with water (7.11 versus 9.10 microg/ml), slightly increased the time to Cmax (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h (AUC(0-12)), the AUC(0-infinity), or the concentration at 12 h. Therefore, grapefruit juice does not clinically significantly affect amprenavir
pharmacokinetics.